Stopping or continuing clopidogrel 12 months after drug-eluting stent placement: the OPTIDUAL randomized trial.
Identifieur interne : 000137 ( Main/Exploration ); précédent : 000136; suivant : 000138Stopping or continuing clopidogrel 12 months after drug-eluting stent placement: the OPTIDUAL randomized trial.
Auteurs : Gérard Helft [France] ; Philippe Gabriel Steg [Royaume-Uni] ; Claude Le Feuvre [France] ; Jean-Louis Georges [France] ; Didier Carrie [France] ; Xavier Dreyfus [France] ; Alain Furber [France] ; Florence Leclercq [France] ; Hélène Eltchaninoff [France] ; Jean-François Falquier [France] ; Patrick Henry [France] ; Simon Cattan [France] ; Laurent Sebagh [France] ; Pierre-Louis Michel [France] ; Albert Tuambilangana [France] ; Nadjib Hammoudi [France] ; Franck Boccara [France] ; Guillaume Cayla [France] ; Hervé Douard [France] ; Abdourahmane Diallo [France] ; Emmanuel Berman [France] ; Michel Komajda [France] ; Jean-Philippe Metzger [France] ; Eric Vicaut [France]Source :
- European heart journal [ 1522-9645 ] ; 2016.
Abstract
This open-label, randomized, and multicentre trial tested the hypothesis that, on a background of aspirin, continuing clopidogrel would be superior to stopping clopidogrel at 12 months following drug-eluting stent (DES) implantation.
DOI: 10.1093/eurheartj/ehv481
PubMed: 26364288
Affiliations:
- France, Royaume-Uni
- Angleterre, Aquitaine, Auvergne-Rhône-Alpes, Grand Londres, Haute-Normandie, Languedoc-Roussillon, Midi-Pyrénées, Nouvelle-Aquitaine, Occitanie (région administrative), Pays de la Loire, Rhône-Alpes, Région Normandie, Île-de-France
- Angers, Bergerac (Dordogne), Bordeaux, Grenoble, Londres, Montpellier, Nîmes, Paris, Rouen, Toulouse
- Université Pierre-et-Marie-Curie
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London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Le Feuvre, Claude" sort="Le Feuvre, Claude" uniqKey="Le Feuvre C" first="Claude" last="Le Feuvre">Claude Le Feuvre</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Georges, Jean Louis" sort="Georges, Jean Louis" uniqKey="Georges J" first="Jean-Louis" last="Georges">Jean-Louis Georges</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Versailles, Le Chesnay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Versailles, Le Chesnay</wicri:regionArea><wicri:noRegion>Le Chesnay</wicri:noRegion><wicri:noRegion>Le Chesnay</wicri:noRegion></affiliation></author><author><name sortKey="Carrie, Didier" sort="Carrie, Didier" uniqKey="Carrie D" first="Didier" last="Carrie">Didier Carrie</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire Rangueil, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire Rangueil, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Dreyfus, Xavier" sort="Dreyfus, Xavier" uniqKey="Dreyfus X" first="Xavier" last="Dreyfus">Xavier Dreyfus</name><affiliation wicri:level="3"><nlm:affiliation>Espace Médical Mounier, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Espace Médical Mounier, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Furber, Alain" sort="Furber, Alain" uniqKey="Furber A" first="Alain" last="Furber">Alain Furber</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire, Angers, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire, Angers</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Angers</settlement></placeName></affiliation></author><author><name sortKey="Leclercq, Florence" sort="Leclercq, Florence" uniqKey="Leclercq F" first="Florence" last="Leclercq">Florence Leclercq</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Eltchaninoff, Helene" sort="Eltchaninoff, Helene" uniqKey="Eltchaninoff H" first="Hélène" last="Eltchaninoff">Hélène Eltchaninoff</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire, Rouen, France INSERM U 1096, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire, Rouen, France INSERM U 1096, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Falquier, Jean Francois" sort="Falquier, Jean Francois" uniqKey="Falquier J" first="Jean-François" last="Falquier">Jean-François Falquier</name><affiliation wicri:level="3"><nlm:affiliation>Polyclinique de Bergerac, Bergerac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Polyclinique de Bergerac, Bergerac</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bergerac (Dordogne)</settlement></placeName></affiliation></author><author><name sortKey="Henry, Patrick" sort="Henry, Patrick" uniqKey="Henry P" first="Patrick" last="Henry">Patrick Henry</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris, Paris 7, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Lariboisière, Assistance Publique Hôpitaux de Paris, Paris 7, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cattan, Simon" sort="Cattan, Simon" uniqKey="Cattan S" first="Simon" last="Cattan">Simon Cattan</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil</wicri:regionArea><wicri:noRegion>Montfermeil</wicri:noRegion><wicri:noRegion>Montfermeil</wicri:noRegion></affiliation></author><author><name sortKey="Sebagh, Laurent" sort="Sebagh, Laurent" uniqKey="Sebagh L" first="Laurent" last="Sebagh">Laurent Sebagh</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Privé de l'Ouest Parisien, Trappes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Privé de l'Ouest Parisien, Trappes</wicri:regionArea><wicri:noRegion>Trappes</wicri:noRegion><wicri:noRegion>Trappes</wicri:noRegion></affiliation></author><author><name sortKey="Michel, Pierre Louis" sort="Michel, Pierre Louis" uniqKey="Michel P" first="Pierre-Louis" last="Michel">Pierre-Louis Michel</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris 6, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Tenon, Assistance Publique Hôpitaux de Paris, Paris 6</wicri:regionArea><wicri:noRegion>Paris 6</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Tuambilangana, Albert" sort="Tuambilangana, Albert" uniqKey="Tuambilangana A" first="Albert" last="Tuambilangana">Albert Tuambilangana</name><affiliation wicri:level="1"><nlm:affiliation>Hôpital Cherbourg, Cherbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Cherbourg, Cherbourg</wicri:regionArea><wicri:noRegion>Cherbourg</wicri:noRegion><wicri:noRegion>Cherbourg</wicri:noRegion></affiliation></author><author><name sortKey="Hammoudi, Nadjib" sort="Hammoudi, Nadjib" uniqKey="Hammoudi N" first="Nadjib" last="Hammoudi">Nadjib Hammoudi</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France IHU, Institute of Cardiometabolism and Nutrition, Hôpital Pitié-Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France IHU, Institute of Cardiometabolism and Nutrition, Hôpital Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Boccara, Franck" sort="Boccara, Franck" uniqKey="Boccara F" first="Franck" last="Boccara">Franck Boccara</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Paris Pierre et Marie Curie, Paris, France INSERM UMR_S 938, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Saint-Antoine, Assistance Publique Hôpitaux de Paris, Paris Pierre et Marie Curie, Paris, France INSERM UMR_S 938, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cayla, Guillaume" sort="Cayla, Guillaume" uniqKey="Cayla G" first="Guillaume" last="Cayla">Guillaume Cayla</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire Nîmes, Université de Montpellier, Nîmes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire Nîmes, Université de Montpellier, Nîmes</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Douard, Herve" sort="Douard, Herve" uniqKey="Douard H" first="Hervé" last="Douard">Hervé Douard</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Diallo, Abdourahmane" sort="Diallo, Abdourahmane" uniqKey="Diallo A" first="Abdourahmane" last="Diallo">Abdourahmane Diallo</name><affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche Clinique Lariboisière St Louis Hôpital Fernand Widal, Assistance Publique Hôpitaux de Paris, Université Paris-Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche Clinique Lariboisière St Louis Hôpital Fernand Widal, Assistance Publique Hôpitaux de Paris, Université Paris-Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Berman, Emmanuel" sort="Berman, Emmanuel" uniqKey="Berman E" first="Emmanuel" last="Berman">Emmanuel Berman</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Komajda, Michel" sort="Komajda, Michel" uniqKey="Komajda M" first="Michel" last="Komajda">Michel Komajda</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France IHU, Institute of Cardiometabolism and Nutrition, Hôpital Pitié-Salpétrière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France IHU, Institute of Cardiometabolism and Nutrition, Hôpital Pitié-Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Metzger, Jean Philippe" sort="Metzger, Jean Philippe" uniqKey="Metzger J" first="Jean-Philippe" last="Metzger">Jean-Philippe Metzger</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Cardiologie, Hôpital Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, boulevard de l'Hôpital, 75013 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name><affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche Clinique Lariboisière St Louis Hôpital Fernand Widal, Assistance Publique Hôpitaux de Paris, Université Paris-Diderot, Paris, France PARTNERS/F-CRIN, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche Clinique Lariboisière St Louis Hôpital Fernand Widal, Assistance Publique Hôpitaux de Paris, Université Paris-Diderot, Paris, France PARTNERS/F-CRIN, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">European heart journal</title><idno type="eISSN">1522-9645</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This open-label, randomized, and multicentre trial tested the hypothesis that, on a background of aspirin, continuing clopidogrel would be superior to stopping clopidogrel at 12 months following drug-eluting stent (DES) implantation.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Grand Londres</li><li>Haute-Normandie</li><li>Languedoc-Roussillon</li><li>Midi-Pyrénées</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Pays de la Loire</li><li>Rhône-Alpes</li><li>Région Normandie</li><li>Île-de-France</li></region><settlement><li>Angers</li><li>Bergerac (Dordogne)</li><li>Bordeaux</li><li>Grenoble</li><li>Londres</li><li>Montpellier</li><li>Nîmes</li><li>Paris</li><li>Rouen</li><li>Toulouse</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Helft, Gerard" sort="Helft, Gerard" uniqKey="Helft G" first="Gérard" last="Helft">Gérard Helft</name></region><name sortKey="Berman, Emmanuel" sort="Berman, Emmanuel" uniqKey="Berman E" first="Emmanuel" last="Berman">Emmanuel Berman</name><name sortKey="Boccara, Franck" sort="Boccara, Franck" uniqKey="Boccara F" first="Franck" last="Boccara">Franck Boccara</name><name sortKey="Carrie, Didier" sort="Carrie, Didier" uniqKey="Carrie D" first="Didier" last="Carrie">Didier Carrie</name><name sortKey="Cattan, Simon" sort="Cattan, Simon" uniqKey="Cattan S" first="Simon" last="Cattan">Simon Cattan</name><name sortKey="Cayla, Guillaume" sort="Cayla, Guillaume" uniqKey="Cayla G" first="Guillaume" last="Cayla">Guillaume Cayla</name><name sortKey="Diallo, Abdourahmane" sort="Diallo, Abdourahmane" uniqKey="Diallo A" first="Abdourahmane" last="Diallo">Abdourahmane Diallo</name><name sortKey="Douard, Herve" sort="Douard, Herve" uniqKey="Douard H" first="Hervé" last="Douard">Hervé Douard</name><name sortKey="Dreyfus, Xavier" sort="Dreyfus, Xavier" uniqKey="Dreyfus X" first="Xavier" last="Dreyfus">Xavier Dreyfus</name><name sortKey="Eltchaninoff, Helene" sort="Eltchaninoff, Helene" uniqKey="Eltchaninoff H" first="Hélène" last="Eltchaninoff">Hélène Eltchaninoff</name><name sortKey="Falquier, Jean Francois" sort="Falquier, Jean Francois" uniqKey="Falquier J" first="Jean-François" last="Falquier">Jean-François Falquier</name><name sortKey="Furber, Alain" sort="Furber, Alain" uniqKey="Furber A" first="Alain" last="Furber">Alain Furber</name><name sortKey="Georges, Jean Louis" sort="Georges, Jean Louis" uniqKey="Georges J" first="Jean-Louis" last="Georges">Jean-Louis Georges</name><name sortKey="Hammoudi, Nadjib" sort="Hammoudi, Nadjib" uniqKey="Hammoudi N" first="Nadjib" last="Hammoudi">Nadjib Hammoudi</name><name sortKey="Henry, Patrick" sort="Henry, Patrick" uniqKey="Henry P" first="Patrick" last="Henry">Patrick Henry</name><name sortKey="Komajda, Michel" sort="Komajda, Michel" uniqKey="Komajda M" first="Michel" last="Komajda">Michel Komajda</name><name sortKey="Le Feuvre, Claude" sort="Le Feuvre, Claude" uniqKey="Le Feuvre C" first="Claude" last="Le Feuvre">Claude Le Feuvre</name><name sortKey="Leclercq, Florence" sort="Leclercq, Florence" uniqKey="Leclercq F" first="Florence" last="Leclercq">Florence Leclercq</name><name sortKey="Metzger, Jean Philippe" sort="Metzger, Jean Philippe" uniqKey="Metzger J" first="Jean-Philippe" last="Metzger">Jean-Philippe Metzger</name><name sortKey="Michel, Pierre Louis" sort="Michel, Pierre Louis" uniqKey="Michel P" first="Pierre-Louis" last="Michel">Pierre-Louis Michel</name><name sortKey="Sebagh, Laurent" sort="Sebagh, Laurent" uniqKey="Sebagh L" first="Laurent" last="Sebagh">Laurent Sebagh</name><name sortKey="Tuambilangana, Albert" sort="Tuambilangana, Albert" uniqKey="Tuambilangana A" first="Albert" last="Tuambilangana">Albert Tuambilangana</name><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Steg, Philippe Gabriel" sort="Steg, Philippe Gabriel" uniqKey="Steg P" first="Philippe Gabriel" last="Steg">Philippe Gabriel Steg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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